Inflammatory response and calcification are strongly implicated in
osteoarthritis (OA) progression. Key inflammatory biomarkers present throughout
the process of OA have been established but an association with calcification
has not been clarified.
A faint line,
tidemark, exists between the subchondral bone and the articular surface in knee
joints that is presumed to be the line of demarcation between calcified and
uncalcified cartilage.
This study shows
that the tidemark is where calcification is actively occurring. Mouse knees
(n=8) were stained for both Alkaline Phosphatase (ALP) and Safranin-O/Fast
Green.
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