Hereditary Multiple Exostoses HME of the Spine; is Really a Benign Bone Tumour Syndrome? Editorial

Hereditary multiple exostoses is the most common type of bone dysplasia, which was first described by Boyer in 1814.

It is characterized by the growth of cartilage-capped benign bone tumours around areas of active bone growth, particularly the long bones metaphysis.

Exostoses can involve all bones, but invariably spare the skull and the face. It is a rare pathology that occurs in around 1 in 50,000 individuals.

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Multiple Finger Extensor Tendon Dislocations in Systemic Lupus Erythematosus with Unique Trigger Phenomena

Dislocation of extensor tendons is the most frequently seen complaint for suffers of rheumatoid arthritis. Here, we present a rare clinical case of multiple finger extensor tendon dislocations in systemic lupus erythematosus (SLE).

Upon physical examination, active extension of middle, ring and little fingers were impossible at the MP joint. A trigger phenomenon was generated when these extensors were reduced in passive extension. The procedure was performed under local anesthesia.

A satisfactory clinical outcome was achieved with sagittal band reconstruction and reinforcement for the site using juncturae tendinum. Surgical intervention under the local anesthesia allowed for extensive gathering of information about repair site strength and dynamic stability.

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Efficacy of Combination Therapy with rhTNFR:Fc and Methotrexate in the Patients with Disease-modifying Antirheumatic Drug -resistant Rheumatoid Arthritis

 To observe the efficacy of combining recombinant human tumour necrosis factor-Fc and methotrexate (MTX) in patients with disease-modifying antirheumatic drug (DMARD)-resistant rheumatoid arthritis.

Collected 64 active RA patients with DMARD-resistant, according to patients’ gender, age, duration and extent of disease activity, divided the 64 patients randomly into comparable two groups. The experimental group within thirty-two patients, were treated with twice-weekly subcutaneous etanercept (25 mg) and meanwhile weekly oral MTX (15 mg).

The control group within thirty-two patients, were treated with daily oral prednisone (5-10 mg) and meanwhile weekly oral MTX (15 mg).Course of treatment is 12 weeks. Clinical response was assessed using American College of Rheumatology (ACR) criteria.

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Vitamin D Deficiency and its Repletion: A Review of Current Knowledge and Consensus Recommendations

In last few years we have witnessed an explosion of research revealing the wide spread prevalence of vitamin D deficiency among all ages, communities, and different disease spectrums.

Clearly, vitamin D has been shown to have effects beyond its traditional role in mineral metabolisms, which are mediated through the activation of vitamin D receptors distributed in a variety of tissues.

There are strong epidemiological links between vitamin D deficiency and chronic diseases and will continue to be a focus of future research. However, this research information has not yet been fully translated into clinical practice.

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The Tibial Pilon Fractures: Are there Problems?

French radiologist Destot primarily used the nomenclature of Tibial Pilon fractures (TPF) to describe distal tibia metaphyseal fractures.

The TPF represent a difficult problem in orthopedic surgical practice because the reduction of these fractures is complex both in the choice of “how” for surgery, both in the choice of “when” (operative timing) for surgery.

Their frequency is relatively low, about 1% of all lower limb fractures, with higher incidence in the 3rd and 5th decade.

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Identification of the Tidemark Line of Calcification in Osteoarthritic Cartilage Using a Stain for Alkaline Phosphatase

Inflammatory response and calcification are strongly implicated in osteoarthritis (OA) progression. Key inflammatory biomarkers present throughout the process of OA have been established but an association with calcification has not been clarified.

A faint line, tidemark, exists between the subchondral bone and the articular surface in knee joints that is presumed to be the line of demarcation between calcified and uncalcified cartilage.

This study shows that the tidemark is where calcification is actively occurring. Mouse knees (n=8) were stained for both Alkaline Phosphatase (ALP) and Safranin-O/Fast Green.

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Effectiveness of Fascial Manipulation on Pain, Grip Strength, and Functional Performance in Chronic Lateral Epicondylitis Patients

Fascial manipulation is an effective tool in the management of the musculoskeletal disorders. This can be used to address pain, grip strength, functional performance in tennis elbow (lateral epicondylitis patients) patients.

The specific objective of the study was to evaluate the efficacy of fascial manipulation in tennis elbow its role in decreasing pain , improving the grip strength and overall functional performance is also evaluated. A total of twenty samples participated in the study.

Reduction in pain intensity was significant, gaining the fascial connection of the neuromusculoskeletal system may also assist patients in accepting why movement of body parts distant from the site of symptoms may be used as a treatment approach to manipulate fascial tissues.

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