Showing posts with label inflammation research journals. Show all posts
Showing posts with label inflammation research journals. Show all posts

Wednesday, 17 May 2017

Aberrant Regulation of Interleukin 18 Binding Protein A (IL-18BPa) by IL-18BPa Autoantibodies in Rheumatoid Arthritis

65 Rheumatoid Arthritis (RA) patients, 22 Osteoarthritis (OA) patients, and 40 sex and age matched healthy donors were enrolled in this study.

Synovial fluids mononuclear cells (SFMC) and peripheral blood mononuclear cells (PBMC) were prepared by using Ficoll-Hypaque separation procedure.
Autoantibodies

Super Array analysis was used to measure the expression profile of immune-related genes in RA synovial tissues (RA-ST) and in normal PBMC treated with recombinant human IL-18 binding protein a (IL-18BPa).

Friday, 17 March 2017

Crystal Induced Arthropathies: A Pictorial Review

Arthropathies

Crystal induced arthropathies are disorders involving crystal deposition in the articular and peri articular soft tissues with resultant inflammation. Gout and calcium pyrophosphate dihydrate (CPPD) crystal deposition disease are the two most common types of crystal- deposition arthritis. The diagnosis is primarily based on clinical and laboratory findings, especially synovial fluid analysis. Radiographs can further aid clinicians in establishing the correct diagnosis.

Acute gout most frequently involves the first metatarsophalangeal (MTP) joint at first presentation. However, it has non-specific radiographic features. Chronic gout has a characteristic radiographic appearance with tophus considered to be a hallmark feature.

Tophi are seen as focal eccentric soft tissue swelling of the affected joints or soft tissues resulting in a "lumpy bumpy appearance" and cause well-defined punched out juxta-articular erosions with sclerotic rims and overhanging edges due to pressure on the adjoining bone