Joint destruction in rheumatoid arthritis (RA)
is due to tissue injury in the area caused by inflammatory reactions, release
of MMPs and free radicals produced by neutrophils and macrophages.
The control of free radical production may
have therapeutic roles thus the study was done to check the status of lipid peroxidation product
malondialdehyde
(MDA) and a few antioxidant enzymes in RA patients.
45 RA patients and 40 controls were selected.
Controls were asymptomatic and RA patients were selected according to ACR
criteria. RA patients had significantly high MDA, SOD and ALP and reduced
activity of catalase and GR as compared to controls. SOD showed positive
correlation with ALP.
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