Knee osteoarthritis (KOA) is an intractable
and devastating consequence of degeneration that results in tremendous impact
on daily activities. Painful disabling KOA occurs in more than 10% of people
who are over 55 years old.
Those who are severely disabled account for up
to 25% of aging people and KOA is a major cause of total knee replacement.
Current osteoarthritis therapies largely rely on rest, weight loss,
bracing and assistive devices, physical modalities, therapeutic exercises,
and pharmacological interventions which are unsatisfactory for the majority of
severe disabled patients, who are left with ambulation deficit despite vigorous
treatment intervention.
Although numerous patients can be treated with
surgery, some of them are not good candidates due to multiple co-morbidities.
For these reasons, intra-articular (IA) treatments that reduce chronic joint
pain and improve function is the long-term effective and safe alternative
options. In a number of recent studies, pain intensity and functional
performance resulted from osteoarthritis has been improved after IA injection
of botulinum toxin type A
No comments:
Post a Comment