Knee osteoarthritis (KOA) is an intractable
and devastating consequence of degeneration that results in tremendous impact
on daily activities. Painful disabling KOA occurs in more than 10% of people
who are over 55 years old.
Those who are severely disabled account for up
to 25% of aging people and KOA is a major cause of total knee replacement.
Current osteoarthritis therapies largely rely on rest, weight loss, bracing and
assistive devices, physical modalities, therapeutic exercises, and pharmacological
interventions which are unsatisfactory for the majority of severe disabled
patients, who are left with ambulation deficit despite vigorous treatment
intervention.
Although numerous patients can be treated with
surgery, some of them are not good candidates due to multiple co-morbidities.
For these reasons, intra-articular (IA) treatments that reduce chronic joint
pain and improve function is the long-term effective and safe alternative
options.
No comments:
Post a Comment